Enhanced expression of TNF-α is associated with liver inflammation and hepatocarcinogenesis[16], also plasma levels of sICAM-1 are not only associated with the risk of incident diabetes and liver disease activity, known predisposing factors for HCC, but furthermore are also a predictive marker of HCC occurrence and prognosis [17], [18], [19], [20], [21], [22]. Here, TNF is linked to hepatocellular carcinoma.