The second reason that a relationship between the ABO blood group and HCC is that the ABO blood group in conjunction with several important cytokines known to be related to HCC development, including EGF, TNF-α, sICAM-1, E-selectin, and P-selectin et al [14], [15], [32], [33], [34]. Here, EGF is linked to hepatocellular carcinoma.