BDNF and Huntington disease: Our assumption on this interaction was not only based on the fact that HD is a neurodegenerative and, hence, progressive disease but also on knowledge about normal Huntingtin whose increased expression leads to protection from apoptotic neuronal cell death after toxic stimuli, neuroprotection from excitotoxicity, and increased transcription of brain-derived neurotrophic factor [18]—all characteristics that may well interfere with the process of aging.