These were MAPK signaling pathway, pathways in cancer, cytokine-cytokine receptor interaction, focal adhesion, chemokine signaling, ECM-receptor interaction, transforming growth factor β (TGF β) signaling pathway etc. As compared to HTR-8/SVneo cells, JEG-3 cells showed an increase in the expression of molecules associated with signaling pathways like renal cell carcinoma, thyroid cancer, insulin signaling, P53 signaling, tight junction etc. This evidence concerns the gene TP53 and hereditary clear cell renal cell carcinoma.