INS and cancer: These were MAPK signaling pathway, pathways in cancer, cytokine-cytokine receptor interaction, focal adhesion, chemokine signaling, ECM-receptor interaction, transforming growth factor β (TGF β) signaling pathway etc. As compared to HTR-8/SVneo cells, JEG-3 cells showed an increase in the expression of molecules associated with signaling pathways like renal cell carcinoma, thyroid cancer, insulin signaling, P53 signaling, tight junction etc.