DACT3 and B-cell chronic lymphocytic leukemia: Although activated Wnt/β-catenin signaling may suppress apoptosis in CLL/SLL cells [33], [34] and DACT3 inhibits this signaling pathway, our findings suggest that suppression of Wnt//β-catenin signaling in pre-CLL/SLL cells may increase susceptibility to CLL/SLL.