Thus, in this paper we seek to identify variants in the cagPAI genes cagC (HP0546), cagE (HP0544), cagL (HP0539), cagV (HP0530), cagT (HP0533), and cag Gamma (HP0523) genes, which have been designated as important functional components of model bacterial T4SS, and are known to be crucial for cagPAI translocation function or present extracellularly, suggesting a possible interactions with host cells; and in cagA, whose EPIYA region has been consistently shown to correlate with clinical outcome (gastric cancer) [16]. This evidence concerns the gene S100A12 and gastric cancer.