The network connecting the SN, nucleus accumbens (NA), and dorsal striatum as well as ventral tegmental area (VTA) is mainly involved in dopaminergic motor pathways, suggesting that CART has the capacity to modulate mesolimbic dopamine, which could have implications for the treatment not only of psychostimulant abuse but also for the treatment of other disorders with midbrain dopamine involvement, such as PD. This evidence concerns the gene CARTPT and Parkinson disease.