In addition, genes involved in epidermal differentiation, including IVL, TGM, SPRR2A/B/E/G, SERPINB7/8, are induced in DM (red bar, Figs. 1A and S2), which have also been shown to be elevated in other inflammatory skin diseases, such as psoriasis and atopic dermatitis [22], [23]. This evidence concerns the gene SPRR2A and inflammatory skin disease.