IFNA1 and dermatomyositis: The fact that many biopsies have high levels of other type I IFN transcripts (which share the same receptor as IFN-beta) in the absence of an IFN signature (Fig. 6C) suggests that other considerations are critical for the strong induction of IFN-induced genes seen in the skin of DM patients—these may include translation of IFN transcripts, localization of IFN production and/or presence of a responder cell population that is sensitive signaling via the IFN receptor.