Conversely, associations with asthma in the PYHIN1 gene were found to be specific to African descent individuals from North America [13], and the only GWAS in asthma conducted to date in Hispanics revealed novel asthma associations in the TLE4-CHCHD9 intergenic region with protective alleles likely to be originated in the Native American ancestral population [12]. Here, PYHIN1 is linked to asthma.