With this premise, previous studies in African-admixed populations have demonstrated that the African genetic ancestry was both associated with risk of asthma and total serum IgE in a Caribbean population [21], and with lower pulmonary function measures in asthmatic and non-asthmatic African Americans [22], [23], the latter suggesting that current diagnosis of severe asthma can be improved if genetic ancestry information is considered for risk assessment [23]. The gene discussed is IGHE; the disease is asthma.