These immunological reagents recognize molecular targets whose expression is tumor associated or/and are essential for the cancer cell survival and proliferation such as the Vascular Endothelial Growth Factor (VEGF), the Epidermal Growth Factor Receptor (EGFR) family, CA125, MUC1, and other signaling pathways which are aberrant in tumor tissue (EpCAM). The gene discussed is EPCAM; the disease is neoplasm.