In fact in healthy subjects, the sIL-2R in men and sIL-6R in women were principally related to IFNγ (Figures 2 and 6), which plays an important role in the development of Th1 cells; in adenoma the TNFα in men and IL-4 in women were, respectively, related to IFNγ and IL-6 (Figures 3 and 6). This evidence concerns the gene IL6R and adenoma.