FN1 and neoplasm: Casey et al. reported that the β1-integrin stimulating antibody or exogenous treatment with fibronectin promoted the spheroid formation of ovarian cancer cells, while blocking antibodies against α5- or β1-integrin inhibited the formation, indicating that interactions between α5β1-integrin and fibronectin mediate the formation of ovarian carcinoma spheroids and their adhesion to ECMs at the secondary tumor growth sites [21].