Consistent with our hypothesis, several independent groups by Padua D et al. and reference therein [21] have found that small-molecule inhibitor of the TGF-β receptors (TGFBR) type I with a human breast cancer cell line, and TGF-β antagonist of the soluble TGFBR2 in a transgenic model decrease the cancer's metastatic capacity. Here, TGFB1 is linked to breast cancer.