Besides, we reported that G3139 (oblimersen sodium, a bcl-2-AS that selectively targets bcl-2 RNA for degradation and decreases Bcl-2 protein; Genta Inc.), if combined with a glutathione (GSH) depleting strategy, facilitates elimination of murine B16-F10 melanoma liver metastases by chemoradiotherapy and biotherapy [11]. This evidence concerns the gene BCL2 and melanoma.