BCL2 and melanoma: In agreement with those findings it was shown, e.g., that a) Bcl-2 promotes invasion and lung metastasis of Bcl-2 overexpressing non-small cell lung cancer cells by inducing matrix metalloproteinase-2 [35]; b) membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth [36]; and c) Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity [37], and regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via HSP90 [38].