Serum cytokine levels (including IL-1α, IL-1β, IL-2, IL-6, IL-10, IL-12, TNF-α, IFN-γ and IFN-α) were lower in A375 melanoma bearing mice treated with G3139 + VRP + ACV + PAC.PBP + DNR + X rays than in controls treated with physiological saline (Table 2). The gene discussed is IL1B; the disease is melanoma.