Side effects included e.g. anemia, severe lymphopenia and neutropenia, and an increase of several tissue-damage-related enzyme activities in plasma, including aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase, alkaline phosphatase, and lactate dehydrogenase (see Additional file 1 Table S3). Here, GPT is linked to neutropenia.