A few papers mentioning a role for c-KIT in thyroid malignancies suggested to perform an analysis of c-KIT expression on thyroid cells obtained by FNAC from benign and malignant thyroid nodules, with the double aim to study a human model of thyroid cancer and, at the same time, to verify if c-KIT expression analysis could be of any clinical interest. This evidence concerns the gene KIT and thyroid nodule.