To see if nutlin-3 can induce similar effects on the gene expression of p21 and BAX as were recently observed explants from a total of four leiomyomas (Table 1) were incubated with nutlin-3 (3 μM and 10 μM each) for 72 h and then checked for the expression of these genes. Here, CDKN1A is linked to leiomyoma.