However, the model based on CBA/J mice infected by PbA exhibits primary features also seen in human CM: a clinical picture including coma, seizures and neurological impairment, strong histopathological similarities with impairment of the blood brain barrier, petechial bleedings and systemic and local immune responses involving TNF, INF-γ and IL-1β as pro-inflammatory cytokines [5,35,37,39]. The gene discussed is TNF; the disease is Coma.