CXCR3 and psoriasis: Similarly, the upregulation of CXCR3 ligands and the increased number of CXCR3+ lymphocytes documented in chronic inflammatory diseases such as rheumatoid arthritis (RA) [14-17], multiple sclerosis (MS) [18,19] and psoriasis [20] indicates the potential importance of CXCR3-mediated leukocyte recruitment in the pathology of these conditions, and suggests the potential utility of the selective CXCR3 antagonist in the treatment and amelioration of these disorders.