Although our results are somewhat limited by the loss of significance for differences at 4 years, we are essentially able to confirm for a real-world setting the results of previous randomized, controlled trials, in which a reduction of new-onset diabetes was reported for renin angiotensin blocking based treatment strategies in comparison to diuretics and/or betablockers in pre-diabetic, hypertensive or cardiovascular risk patients. The gene discussed is REN; the disease is diabetes mellitus.