FGF2 and neoplasm: In 2000, Browder and colleagues (1) reported that frequent systemic administration or continuous infusion with cyclophosphamide at a minimally toxic dose inhibited basic fibroblast growth factor (bFGF)-mediated angiogenesis in the mouse corneal micropocket assay, induced the apoptosis of vascular endothelial cells (ECs) in tumor microvessels, and suppressed the growth of transplantable mouse tumors.