In the same year, Klement and coworkers (2) reported on the following effects of frequent intraperitoneal (i.p.)injections of low dosages of vinblastine in mice: (i) no significant effect on body-weight; (ii) significantly reduced vascularity of subcutaneous (s.c.)Matrigel pellets that contained bFGF; (iii) significant albeit transient xenograft tumor regression; (iv) diminished tumor vascularity; and (v) direct inhibition of tumor angiogenesis in SCID mice. This evidence concerns the gene FGF2 and neoplasm.