However, data emerging from experimental models of atherosclerosis indicate that IFN-γ, TNF-α, and CD40 ligand (CD154) produced by Th-1 CD4+ T-cell responsive to antigens in oxidized LDL drive plaque macrophages to produce reactive oxygen species, NO, and proinflammatory cyto/chemokines [73]. Here, CD40LG is linked to atherosclerosis.