Another recent study reports that gamma-tocotrienols (gamma-T3) and vitamin-E constituents, downregulate the expression of PCa stem cell markers (CD133/CD44) in androgen-independent prostate cancer cell lines (PC-3 and DU145), suppress tumor initiation ability of these cells, and chemosensitizes PC-3 to taxotere [69]. This evidence concerns the gene CD44 and posterior cortical atrophy.