When PTEN is lost on chromosome 10 (which occurs in more than 20% of PCa with Gleason ≥7), the phosphatidylinositol 3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is activated leading to phosphorylation of the AR (→ hypersensitive AR), and increase of cell proliferation by downregulating p27 [17]. Here, AKT1 is linked to posterior cortical atrophy.