The Cav-2 gene was colocalized with the Cav-1 gene to the locus D7S522 of human chromosome 7q31.1, a known fragile site (FRA7G) that is frequently deleted in human cancers, including squamous cell carcinomas of the head and neck, prostate cancers, renal cell carcinomas, ovarian adenocarcinomas, colon carcinomas, and breast cancers [26]. The gene discussed is CAV2; the disease is breast cancer.