Independently, using freeze-fracture immunoelectron microscopy, Fujimoto and colleagues [15] have shown that coexpression of Cav-1 and Cav-2 resulted in a more efficient formation of deep caveolae than Cav-1 alone in hepatocellular carcinoma cell line (HepG2). The gene discussed is CAV2; the disease is hepatocellular carcinoma.