As expected on the basis of lipid droplet targeting of Cav-2, later studies also implicated Cav-2 in regulating lipid metabolism due to changes in its expression levels associated with obesity and type 2 diabetes mellitus or adenoviral overexpression studies [43, 44]; however, the direct role of Cav-2 and its alpha versus beta isoforms in these processes remains still unclear. Here, CAV2 is linked to obesity due to melanocortin 4 receptor deficiency.