This is in agreement with Hassan et al (17) who revealed significantly higher expression levels of HOXD10 in OSCC compared to those in normal oral mucosa, as well as higher expression levels in dysplasia tissues compared to normal oral mucosa tissues, suggesting that HOXD10 expression sequentially alters from normal mucosa, to dysplasia and OSCC. The gene discussed is HOXD10; the disease is dysplasia.