In a previous analysis, we compared the presence of CD1a+ve phenotype, SIL-TAL1 status, TLX3 abnormal expression and the clinical features on the impact in the prognosis of T-ALL in series of Brazilian children and young adults [6]; whereas the presence of SIL-TAL1 had a poor outcome, particularly in younger children, either ectopic TLX3 or immunophenotyping were not predictive factors for outcome corroborating with data described by the Dutch Childhood Oncology Group [25]. Here, TLX3 is linked to acute lymphoblastic leukemia.