If the cutoff value is > 280 μg/L for VEGF and > 35 μg/L for Ang-2, the incidence of VEGF and Ang-2 abnormality were 87.0% and 94.7% in HCC, 16.2% and 2.7% in liver cirrhosis, 13.3% and 0% in chronic hepatitis, and none in the normal control, respectively. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.