In a previous pilot study we demonstrated that six recently identified marker genes (ADM3/HGD1/LGALS3/PLAB/TFF3/TG) can be successfully applied for a molecular discrimination of benign and malignant thyroid tumours including follicular thyroid neoplasia (Krause et al, 2008) using surgically removed tissue samples. The gene discussed is TFF3; the disease is thyroid cancer.