SNCA and Parkinson disease: Significant tau pathology has also been noted in some monogenic forms of PD, including in some cases resulting from LRRK2 mutation and in some members of the Contursi kindred, who carry the A53T SNCA mutation, as well as in α-synuclein overexpressing transgenic mice (Devine and Lewis, 2008; Haggerty et al., 2011).