In an early work, low p27 expression, classified as < 50% of cells p27 positive, correlated with a number of prognostic morphologic features (including Gleason score, positive surgical margins, seminal vesicle involvement, lymph node metastasis and tumor aneuploidy) but did not correlate with sub-clinical biochemical failure, concurring with our results [21]. Here, CDKN1B is linked to metastatic malignant neoplasm in the lymph nodes.