In this study we have simultaneously examined the immunohistochemical expression of p16 and p27 in RP specimens of hormone naïve PC patients and reported the absence of a prognostic role for p16 and p27 in primary PC, as we observed no correlations with most important, firmly established clinico-pathological parameters, including pre-operative PSA, tumor stage and grade, even at the univariate level. The gene discussed is CDKN2A; the disease is neoplasm.