CRP and Plasmodium falciparum malaria: To illustrate this in more detail: when a hypothetical decision rule for severe malaria was constructed solely based on CRP and applied to the current study population, 16% of the evaluable patients with non-severe, non-falciparum malaria and 22% of the evaluable patients with non-severe P. falciparum malaria would have been falsely diagnosed as having severe malaria, whereas the diagnosis severe malaria would not have been considered in 21% of the evaluable patients with severe disease.