HMOX1 and diabetes mellitus: The effect of HO-1 in preventing progression of overt diabetes was confirmed by another study in which HO-1 was induced in female NOD mice at 9 weeks of age with a single intravenous injection of a recombinant adeno-associated virus bearing the HO-1 gene (AAV-HO-1, 0.5 × 1010 – 2.5 × 1010 viruses/mouse).