TF and acute leukemia: Similarly, in cells from patients with acute promyelocytic leukemia (APL) the t(15;17) chromosomal translocation induces hyperexpression of tissue factor (TF) and renders the patient hypercoagulable.5 Patients with acute leukemias very often present with a range of laboratory abnormalities consistent with the diagnosis of disseminated intravascular coagulation (DIC) and a variety of clinical manifestations, ranging from localized venous or arterial thrombosis to diffuse life-threatening bleeding.