TF and acute promyelocytic leukemia: In these cells, the t(15;17) translocation, which results in the fusion of the nuclear retinoic acid receptor (RAR-alpha) gene on chromosome 17 with part of the PML (promyelocytic leukemia) gene on chromosome 15, induces hyperexpression of TF, again linking the primary oncogenic event with induction of hypercoagulability.8