In these cells, the t(15;17) translocation, which results in the fusion of the nuclear retinoic acid receptor (RAR-alpha) gene on chromosome 17 with part of the PML (promyelocytic leukemia) gene on chromosome 15, induces hyperexpression of TF, again linking the primary oncogenic event with induction of hypercoagulability.8 This evidence concerns the gene RARA and acute promyelocytic leukemia.