NRAS and acute myeloid leukemia: The prognostic impact of NRAS mutations is still under research and seems to vary from disease to disease,14 several studies indicated a poor prognostic impact for that mutation,14,15 and however Lapillonne et al confirmed this finding in pediatric AML.16 On the contrary, Neubauer et al found a favorable outcome for malignancies with NRAS mutations,12 and some studies failed to define any prognostic impact for NRAS mutations.10,13,17