Beside that, we have also demonstrated the importance of Ae-Og and ascorbic acid to exert a new anti-inflammatory drug to combat against nicotine-induced immune disorder; our results clearly established that cotreatment of Ae-Og and ascorbic acid with nicotine can diminish the nicotine-induced enhanced Th1 cytokines (TNF-α and IL-12) release and in mRNA level as well as boost up the Th2 (IL-10 and TGF-β) cytokine release and mRNA level up to more or less control level (Figure 3). Here, TNF is linked to immune system disorder.