ESR1 and neoplasm: Unmethylated CXCR4 was not significantly associated with the age of disease onset (p = 0.466), estrogen receptor status (p = 0.310), HER2 expression (p = 0.276), progesterone receptor status (p = 0.117), tumor recurrence (p = 1.000) or histological type (p = 0.849).