CXCR4 and neoplasm: However, unmethylated CXCR4 did correlate with the tumor stage (p<0.001), tumor size (p<0.001), histological grade (p<0.001), SBR grade (p<0.001), lymph node status (p = 0.002), metastasis (p = 0.026) and death (p = 0.038).