FCGR2A and viral infectious disease: Unlike the previously identified FcγRI and FcγRIIa mediating ADE of virus infection, poFcγRIIb is an inhibitory FcγR that can prevent activation of immune cells by recruitment of SHIP (Src Homology 2-containing 5′-inositol phosphatase) to its cytoplasmic ITIM (immunoreceptor tyrosine-based inhibition motif) [18].