A significant negative association of MBL deficiency (<100 ng/mL) was observed with LL patients when compared with controls and TT patients, suggesting a protective role for MBL deficiency against the development of the most severe MB form of leprosy [63] explained because MBL deficiency could be advantageous against intracellular pathogens that exploit complement deposition on their surface to enhance uptake into phagocytes such as the case of M. leprae [14, 60]. This evidence concerns the gene MBL2 and leprosy.