TLR1 and leprosy: The T1805G (rs5743618 or I602S) variant presumably downregulates TLR1 expression on the cell surface and also causes abnormal signaling [83, 84] and has been associated with a decreased incidence of leprosy and with protection against reversal reaction [83] probably diminishing antimycobacterial cathelicidin (LL-37) expression [4, 5].