The correlated TH1-cell-mediated immune (CMI) response (IL-2, IL-6, IL-12, IFN-γ, and TNF) promotes the formation of delineated granulomas—central areas of infected macrophages, often fused into multinucleate giant cells, surrounded by T cells—which suggested function in infection control is still controversial [16, 17] and data on M. marinum suggesting a role in infection dissemination seems interesting to test in human leprosy [18]. Here, TNF is linked to infection.