The tumor immune escape refers to the mechanism by which the body maximizes immune tolerance, through the production of soluble immunosuppressive factors (Interleukin (IL)-10, transforming growth factor-beta1 (TGF-β1), tumor-infiltrating cells such as macrophages and granulocytes), and the recruitment of suppressive cells of the adaptive and innate immune system. This evidence concerns the gene TGFB1 and neoplasm.