Also, another group demonstrated, using HeLa cells, that the administration of specific siRNAs for HPV18 E6 generated in lentivirus, combined with cisplatin, the drug most frequently used in the treatment of advanced CC, produces the silencing of HPV18 E6 and E7 oncogenes, an increase in p53 expression and death of cancer cells by cellular senescence [86]. Here, TP53 is linked to cancer.