We modeled the mechanism of AD mediating this protection by having AD convert SOFF into SAD, a form of S preserved from the desensitization pathways leading to SIN2 or SPKA, but similar to SOFF in its ability to become activated by 5HT and cause the translocation of PKC Apl II (Figure 2, black, maroon and red pathway; equations can be found in the Materials and Methods section). This evidence concerns the gene PRRT2 and Alzheimer disease.