Neither of the two SNPs showed significant association between high myopia (Spherical refraction ≤-6.00D) and controls (p>0.05), the association results of the SNPs (rs2075555 and rs2269336) in COL1A1 and high myopia in a Han Chinese cohort are listed in Table 2 and Table 3, respectively. This evidence concerns the gene COL1A1 and myopia.