Finally, a study of the association between SNPs in the COL1A1/COL2A1 gene and high myopia in Caucasian family data sets comprising 146 (Duke) and 130 (Cardiff) families with high myopia found that COL1A1 gene variants were not associated with myopia, while COL2A1 was associated with high myopia in two independent Caucasian family data sets [36]. The gene discussed is COL2A1; the disease is myopia.