Although the involvement of EMID2 in various human diseases remains to be elucidated, the relevance of ECM deposition and subepithelial fibrosis in diseases of the airways as well as the expression of HSP47 in nasal mucosa [6] suggest that EMID2 may play a role in the development of nasal polyps. The gene discussed is SERPINH1; the disease is nasal cavity polyp.