After being respectively treated with UTI, TXT and UTI+TXT for 48h, the gene expression of IGF-1R, PDGFA, NGF, NF-κB, and JNK2 in human breast cancer cells decreased significantly compared with the control group (P < 0.05; Figure 6, Figure 7a, b, c, d, e) in the order of UTI+TXT > TXT > UTI > control. Here, IGF1R is linked to bacterial urinary tract infection.