FMO5 and chronic asthma: All the classical features of a robust acute allergenic asthma phenotype are significantly amplified in the KO mice showing that NADPH oxidase, which is essentially an extra-cellualr matrix associated enzyme expressed by phagocytes, which by definition may denote a non-specific inflammatory response or at the best an inflammatory phenomenon associated with lung remodeling in chronic asthma, surprisingly may also have a regulatory role in the sensitization or priming stage.