TNF and major depressive disorder: Though an association between CRP and depressive disorder was lacking, a possible association of inflammation cannot be excluded in this sample, considering that association with depression of inflammatory mediators other than CRP (chemokines and cytokines such as MCP-1, MIP-1α, TNFα, IL-1β, IL-6, interferon activity, etc. [30]) originating from tissues other than adipose tissue such as macrophages and T cells [11] has been demonstrated.