In fact, to date, there have been only three positive clinical trials in critically ill adults with sepsis–early goal-directed therapy (EGDT) [22], activated protein C (drotrecogin alfa, Xigris, Eli Lilly and Co, Indianapolis, IN) [23], and afelimomab, a monoclonal antibody F(ab')2 fragment directed against tumor necrosis factor (TNF)-α [24]. This evidence concerns the gene TNF and Sepsis.