Finally, a small but exceptionally tightly correlated metagene, called Inflame (Fig. 3), contained about 250 genes upregulated with AD, including many inflammation markers, such as IL1B, IL10, IL16, IL18, and HLA genes, as well as markers of macrophages, such as VSIG4, SLC11A1, and apoptosis, such as CASP1/4, TNFRSF1B (p75 death receptor) (Table 2, S2, Fig. S4). The gene discussed is CASP1; the disease is Alzheimer disease.