NPSR1 and inflammatory bowel disease: As shown in Table 2, where the results obtained from the analysis of the remaining SNPs are reported, we detected significant association with reduced risk of IBD for the functional haplotype rs2530547C-rs324981A-rs727162C (OR = 0.78; P = 0.0097), which is composed by alleles corresponding to increased NPSR1 mRNA expression (-103C) and weaker intracellular signalling (107Asn and 241Ser) at the respective polymorphic positions.