The present study examined whether anti-HSV antibodies were associated with plasma Aβ1–40, Aβ1–42 and Aβ1–42-to-Aβ1–40 ratio in a sample of older community dwellers from the Three-City study, and whether this association may be modulated by genetic risk factors for AD; Apolipoprotein E-allele e4 (ApoE4), CR1 and CLU, which have also been involved in the HSV life cycle [2], [9]. This evidence concerns the gene CLU and Alzheimer disease.