We also performed KEGG pathway analysis for the DRM genes and found that genes with hypermethylated promoters were enriched in the following KEGG pathways including 11 genes in hsa04010 (MAPK signaling pathway), 18 genes in hsa05200 (Pathways in cancer), 5 genes in hsa04310 (Wnt signaling pathway), 5 genes in hsa00982 (Drug metabolism), and 5 genes in hsa04115 (p53 signaling pathway) (Table 3). The gene discussed is TP53; the disease is cancer.