APC and neoplasm: Although there was not a significant increase in the mean tumor burden in the MMTV-PyMT;ApcMin/+ mice, significantly more MMTV-PyMT;ApcMin/+ mice (10/21) had tumor burden (i.e. total tumor volume per mouse) greater than the mean tumor burden (977.6±212 mm3) for the MMTV-PyMT;Apc+/+ control mice at 65 days of age (Figure 2D; p≤0.05 by exact binomial goodness-of-fit test).