F2 and venous thromboembolism: More importantly, previous studies have associated S219G with increased risk of venous thromboembolism [33], [34]; moreover, a haplotype including S219G has been associated with increased risk of venous thromboembolism in carriers of (i) Factor V Leiden [35]; (ii) the G20210A mutation in the prothrombin gene [36]; and (iii) other dysfunctional PC variants [32].